The Sir2-Sum1 complex represses transcription using both promoter-specific and long-range mechanisms to regulate cell identity and sexual cycle in the yeast Kluyveromyces lactis.

Deacetylases of the Sir2 family regulate lifespan and response to stress.We have examined the evolutionary history of Sir2 and Hst1, which arose by gene duplication in budding yeast and which participate in distinct mechanisms of gene repression.In Saccharomyces cerevisiae, Sir2 interacts with the SIR complex to generate long-range silenced chromat

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